Fkbp4 CLIA Kit for Rat(Rattus norvegicus) | EIAab.comFkbp4 CLIA Kit for Rat(Rattus norvegicus)

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Fkbp4 (Gene name),

Peptidyl-prolyl cis-trans isomerase FKBP4 (Protein name ), FKBP4_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Fkbp4(Fkbp52);

Protein name:

Peptidyl-prolyl cis-trans isomerase FKBP4(PPIase FKBP4);

Alternative:

59 kDa immunophilin(p59);52 kDa FK506-binding protein(52 kDa FKBP;FKBP-52);FKBP59;FK506-binding protein 4(FKBP-4);Immunophilin FKBP52;HSP-binding immunophilin(HBI);Rotamase;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Homodimer (By similarity). Associates (via TPR domains) with HSP90 and HSP70 in unactivated steroid hormone receptor complexes. Also interacts with peroxisomal phytanoyl-CoA alpha-hydroxylase (PHYH) (By similarity). Interacts with NR3C1 and dynein. Interacts with HSF1 in the HSP90 complex (By similarity). Associates with tubulin (By similarity). Interacts with MAPT/TAU; the interaction is enhanced for phosphorylated MAPT/TAU. Interacts (via TPR domain) with S100A1, S100A2 and S100A6; the interaction is Ca(2+) dependent (By similarity). Interaction with S100A1 and S100A2 (but not with S100A6) leads to inhibition of FKBP4-HSP90 interaction.

Function:

Immunophilin protein with PPIase and co-chaperone activities (By similarity). Component of unliganded steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90) (By similarity). Play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments (By similarity). Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. The PPIase activity controls neuronal growth cones via regulation of TRPC1 channel opening.

Subcellular Location:

Cytoplasm cytosol Nucleus Cytoplasm cytoskeleton Colocalized with MAPT/TAU in the distal part of the primary cortical neurons.

Protein Attributes:

Sequence length:

458

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

458:

QAQVKTEA

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

rno:260321

String:

Q9QVC8

UniGene:

Rn.23741

Pfam:

PF00254

Uniprot:

Q9QVC8

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ELISA Kit for Rat PPIase FKBP4

Cat.:

E11170h

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96T

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ELISA Kit for Rat PPIase FKBP4

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ELISA Kit for Rat PPIase FKBP4

Cat.:

E11170m

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96T

ELISA Kit for Rat PPIase FKBP4

Cat.:

E11170r

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96T

ELISA Kit for Rat PPIase FKBP4

Cat.:

E11170b

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Packing:

96T

CLIA Kit for Rat PPIase FKBP4

Cat.:

U11170r

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Packing:

96T

CLIA Kit for Rat PPIase FKBP4

Cat.:

U11170m

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Packing:

96T

CLIA Kit for Rat PPIase FKBP4

MSDS:

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CLIA Kit for Rat PPIase FKBP4

Cat.:

U11170b

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Packing:

96T

CLIA Kit for Rat PPIase FKBP4

Cat.:

U11170h

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Manual:

Looking for manual.

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96T

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Polyclonal Antibody for Rat PPIase FKBP4

Cat.:

P11170Rb-r

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40ug/0.2ml

Polyclonal Antibody for Rat PPIase FKBP4

Cat.:

P11170Rb-m

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40ug/0.2ml

Polyclonal Antibody for Rat PPIase FKBP4

Cat.:

P11170Rb-h

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40ug/0.2ml

Monoclonal Antibody for Rat PPIase FKBP4

Protein for Rat PPIase FKBP4

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
2.

"Association of a 59-kilodalton immunophilin with the glucocorticoid receptor complex."
Tai P.-K.K. , Albers M.W. , Chang H. , Faber L.E. , Schreiber S.L.
Science256:1315-1318(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-25
tissue: Leukemia.
3.

Desai B.J. , McKinney K.Q. , Meyer M.H. , Bahrani-Mostafavi Z. , Meyer R.A. Jr.
Submitted (2002-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 57-458
strain: Sprague-Dawley.
tissue: Brain.
4.

"The immunophilin FKBP52 specifically binds to tubulin and prevents microtubule formation."
Chambraud B. , Belabes H. , Fontaine-Lenoir V. , Fellous A. , Baulieu E.E.
FASEB J.21:2787-2797(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH TUBULIN
5.

"A role for FKBP52 in Tau protein function."
Chambraud B. , Sardin E. , Giustiniani J. , Dounane O. , Schumacher M. , Goedert M. , Baulieu E.E.
Proc. Natl. Acad. Sci. U.S.A.107:2658-2663(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;INTERACTION WITH MAPT
6.

Maurya D.K. , Bhargava P.
Submitted (2009-01) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY

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